Agenda
When sample size $n$ is large, the distribution of $\hat{\theta}$ becomes approximately normal:
$$ \hat{\theta} \sim N \left( \theta, \frac{1}{n I(\theta)} \right) $$
where $I(\theta)$ is the Fisher information. This result us to use MLEs as unbiased, efficient estimators with minimal variance in large samples.
Recall, the Fisher Information is given by,
$$ I(\theta) = -\mathbb{E} \left[ \frac{\partial^2}{\partial \theta^2} \log L(\theta; X) \right] $$
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The Cramér-Rao Lower Bound: provides a theoretical lower limit for the variance of any unbiased estimator $\hat{\theta}$ of a parameter $\theta$. According to the CRLB, for an unbiased estimator:
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$$ \text{Var}(\hat{\theta}) \geq \frac{1}{n I(\theta)} $$
where $n$ is the sample size and $I(\theta)$ is the Fisher information.
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Efficient estimator: an estimator that achieves the CRLB, it has the smallest possible variance among unbiased estimators.
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To construct a confidence interval for an MLE $\hat{\theta}$, we use its approximate normal distribution in large samples:
$$ \hat{\theta} \sim N \left( \theta, \frac{1}{n I(\theta)} \right) $$